Under-ascertainment of Respiratory Syncytial Virus infection in adults due to diagnostic testing limitations

In 2022, the P95 team collaborated on a systematic review and meta-analysis to quantify testing under-ascertainment of adult respiratory syncytial virus (RSV) infection. A total of 8066 unique references were screened, of which 154 met the inclusion criteria. The analysis showed that RT-PCR, particularly singleplex testing, is the most sensitive RSV diagnostic test in adults and that accuracy can be improved by assessing ≥3 specimen types.