Public health impact of low-dose aspirin on colorectal cancer, cardiovascular disease and safety in the UK (statistics/IT)

An individual’s risk of cardiovascular disease and colorectal cancer may be decreased by prophylactic low-dose aspirin therapy. However, this therapy is also associated with adverse effects such as bleeding. To evaluate the expected population-level effect of low-dose aspirin prophylaxis, a micro-simulation model was built with data from UK governmental agencies and recent publications. The model demonstrated that the decrease in the incidence rate and the number of fatal cardiovascular disease and colorectal cancer events was larger than the increase in the incidence rate and number of fatal adverse effects in the UK population indicated for such prophylaxis. P95 contributed to the study design, data collection, model development, and study document writing and editing. 

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