qualitative burden of disease study: patients with ied aged ≥ 60 years in the United States
Background Invasive Escherichia coli disease (IED) comprises a diverse range of severe infections caused by E. coli, mainly affecting neonates and older adults, and is associated with severe and...
Systematic Literature Review: Burden of hMPV in Older and High-Risk Adults in Developed Countries
Introduction Human metapneumovirus (hMPV) causes respiratory infections in individuals of all age groups. While the evidence on hMPV epidemiology is growing, the hMPV burden in adults has not been...
COVID-19 vaccine effectiveness study against JN.1 variant using id.DRIVE platform
Background Prior studies have reported lower effectiveness of XBB.1.5-adapted vaccines against hospitalization related to the COVID-19 Omicron JN.1 variant than the XBB variant. This study evaluated...
Protocol development: Observational study EAGLE
Abstract Background: Immunocompromised individuals are known to respond inadequately to SARS-CoV-2 vaccines, placing them at high risk of severe or fatal COVID-19. Thus, immunocompromised...
Qualitative study on COVID-19 avoidance behavior after lockdown
Abstract Background: This exploratory qualitative study involved semi-structured interviews with adults and caregivers of adults at high risk of severe COVID-19, addressing current COVID-19...
Systematic Literature Review: Effect of pneumococcal conjugate vaccines on viral respiratory infections
In addition to preventing pneumococcal disease, emerging evidence indicates that pneumococcal conjugate vaccines (PCVs) might indirectly reduce viral respiratory tract infections (RTIs) by affecting pneumococcal-viral interactions.
Symptomatic Respiratory Syncytial Virus Infection Incidence in Adults in Multiple Countries
Estimating respiratory syncytial virus (RSV) burden in adults is challenging because of non-specific symptoms, infrequent standard-of-care testing, resolution of viral shedding before seeking medical care, test positivity that varies by specimen site in the upper airway and lower diagnostic test sensitivity compared to children.
Respiratory Syncytial Virus-Related Hospitalizations and Deaths Among Children and Adults in Spain
Respiratory syncytial virus (RSV) causes a substantial disease burden among infants. In older children and adults, incidence is underestimated due to nonspecific symptoms and limited standard-of-care testing. We aimed to estimate RSV-attributable hospitalizations and deaths in Spain during 2016-2019.
Enabling the evaluation of COVID-19 vaccines with correlates of protection
In February 2023, a meeting about correlates of protection (CoPs) against COVID-19 was organized by the International Alliance for Biological Standardization, the European Plotkin Institute for Vaccinology, and Vaccinopolis. The meeting aimed at reviewing the evidence, drawing conclusions, and identifying knowledge gaps.
COVIDRIVE: AZD1222 vaccine effectiveness against hospitalisation
Vaccine effectiveness (VE) studies with long-term follow-up are needed to understand durability of protection against severe COVID-19 outcomes conferred by primary-series vaccination in individuals not receiving boosters. COVIDRIVE is a European public-private partnership evaluating brand-specific vaccine effectiveness (VE). We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.